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Abstract Title:

Polyphenols rich Passiflora leschenaultii leaves modulating Farnesoid X Receptor and Pregnane X Receptor against paracetamol-induced hepatotoxicity in rats.

Abstract Source:

Biomed Pharmacother. 2017 Apr ;88:1114-1121. Epub 2017 Feb 10. PMID: 28192885

Abstract Author(s):

Saravanan Shanmugam, Dhivya Sivaraj, Bruno Dos Santos Lima, Paula Dos Passos Menezes, Yasmim Maria Barbosa Gomes de Carvalho, Adriano Antunes de Souza Araújo, Narendra Narain, Mairim Russo Serafini, Lucindo José Quintans Júnior, Luciana Scotti, Marcus Tulius Scotti, Thangaraj Parimelazhagan

Article Affiliation:

Saravanan Shanmugam

Abstract:

The hepatoprotective effect of P. leschenaultii. (DC) leaves was investigated in rats under paracetamol induced oxidative stress. Leaf acetone extract (200 and 400mg/kg) were administered daily via gavage for 14days before paracetamol (2000mg/kg, p.o.) treatment. After the experiment, the levels of serum biochemical parameters and enzymatic antioxidant levels were determined. Furthermore, liver tissues were analyzed histopathologically. Additionally, the molecular docking studies of the identified compounds against PXR and FXR proteins were also performed. The assessment revealed that the acetone extract significantly reduced the elevated levels of SGPT, SGOT and ALP in serum. Moreover, the enzymatic antioxidants such as SOD, CAT and LPO were also retained normally by the plant extract. From histopathological analysis, it was clearly evident that the cellular architecture of plant extract treated rat liver tissues were not affected by the paracetamol induction at the higher dose. The results of docking studies also revealed that the identified compounds showed steric interactions (between nonpolar atoms) with amino acid groups. Collectively, the present study suggests that P. leschenaultii leaves extract protects the liver from paracetamol induced hepatic damage.

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