ORAL ADMINISTRATION OF BANANA LECTIN MODULATES CYTOKINE PROFILE AND ABUNDANCE OF T-CELL POPULATIONS IN MICE.
Int J Biol Macromol. 2016 Apr 19. Epub 2016 Apr 19. PMID: 27106589
Ana Claudia Miranda Brito Sansone
Banana lectin (BanLec) is a dimeric protein occurring in fruit pulp that modulates immune cell functioning in vitro. In order to assess the immune response in vivo, BanLec from ripe banana (Musa acuminata) fruit was purified and orally given to mice for seven days. The analysis of cytokines in the mice peripheral blood revealed increased IL-10, IL-17 and TNFα, and a reduction of IFNγ and IL-6. In the thymus, an increase of CD4+ and a decrease of CD8+ T-cells were observed after oral administration of BanLec. The modulation of pro- and anti-inflammatory cytokines and T-cells in the peripheral blood and thymus of mice demonstrated the immunomodulatoryproperties of natural BanLec in vivo. This research brings new data on a protein from a fresh fruit consumed worldwide that may act as an immunomodulator, potentially affecting the host response to infections, immune diseases and cancer.