Oleuropein blocks hepatitis B virus replication. - GreenMedInfo Summary
Antiviral efficacy against hepatitis B virus replication of oleuropein isolated from Jasminum officinale L. var. grandiflorum.
J Ethnopharmacol. 2009 Sep 7;125(2):265-8. Epub 2009 Jul 4. PMID: 19580857
Institute of Radiation Medicine, Academy of Military Medical Science, Haidian District, Beijing 100850, China.
ETHNOPHARMACOLOGICAL RELEVANCE: Jasminum officinale L. var. grandiflorum (JOG) is a folk medicine used for the treatment of hepatitis in south of China. Phytochemical studies showed that secoiridoid glycosides are the typical constituents of this plant. AIM OF THE STUDY: The present study was undertaken to evaluate the effect of oleuropein (Ole) derived from the flowers of JOG on hepatitis B virus (HBV) replication in HepG2 2.2.15 cell line in vitro and duck hepatitis B virus (DHBV) replication in ducklings in vivo. MATERIAL AND METHODS: The extracellular hepatitis B e antigen (HBeAg) and hepatitis B surface antigen (HBsAg) concentrations in cell culture medium were determined by ELISA. DHBV in duck serum was analyzed by dot blot. RESULTS: Ole blocks effectively HBsAg secretion in HepG2 2.2.15 cells in a dose-dependent manner (IC(50)=23.2 microg/ml). Ole (80 mg/kg, intraperitoneally, twice daily) also reduced viremia in DHBV-infected ducks. CONCLUSION: Ole therefore warrants further investigation as a potential therapeutic agent for HBV infection.