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Abstract Title:

Neuroprotective Effects of Oleocanthal, A Compound in Virgin Olive Oil, in A Rat Model of Traumatic Brain Injury.

Abstract Source:

Turk Neurosurg. 2017 Nov 1. Epub 2017 Nov 1. PMID: 29204981

Abstract Author(s):

Mesut Mete, Isıl Aydemir, Ulkun Unlu Unsal, Fatih Collu, Gokhan Vatandas, Beyhan Gurcu, Yusuf Kurtulus Duransoy, Fatma Taneli, Mehmet Ibrahim Tugrul, Mehmet Selcuki

Article Affiliation:

Mesut Mete

Abstract:

AIM: TBI has two distinct phases: primary and secondary injury. Many agents have been used to prevent secondary injury. Oleocanthal (OC) has anti-inflammatory and antioxidant properties similar nonsteroidal anti-inflammatory drug. We evaluated the neuroprotective effects of OC in a rat model of TBI.

MATERIAL AND METHODS: Twenty-six adult male, Wistar albino rats were used. The rats were divided into 4 groups. group 1, sham (n = 5). group 2, trauma (n = 5): Rats were treated with 10 mg/kg saline intraperitoneally (IP) twice a day. Groups 3 and 4, rats were treated with 10 (group 3, n = 8) or 30 (group 4, n = 8) mg/kg OC IP twice a day. For each group brain samples were collected 72 h after injury. Brain samples and blood were evaluated with histopathological and biochemical methods.

RESULTS: Histopathological evaluation revealed a significant difference between group 2 and group 4. Biochemical findings demonstrated that, oxidative stress index was the highest in group 2 and was the lowest in the group 4.

CONCLUSION: Results indicated that OC has a protective effect on neural cells after TBI. This effect is achieved by reducing oxidative stress and apoptosis.

Study Type : Animal Study

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