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Abstract Title:

Anti HIV-1 flavonoid glycosides from Ochna integerrima.

Abstract Source:

Planta Med. 2007 Jun;73(7):683-8. Epub 2007 Jun 11. PMID: 17562490

Abstract Author(s):

Vichai Reutrakul, Niwat Ningnuek, Manat Pohmakotr, Chalobon Yoosook, Chanita Napaswad, Jitra Kasisit, Thawatchai Santisuk, Patoomratana Tuchinda

Article Affiliation:

Department of Chemistry, Faculty of Science, Mahidol University, Bangkok, Thailand. scvrt@mahidol.ac.th

Abstract:

Bioassay-guided fractionation of the anti-HIV-1 active EtOAc extract from leaves and twigs of Ochna integerrima led to the isolation of five new flavonoid glycosides 1 - 5, five known flavonoids 6 - 10, and two known flavonoid glycosides 11 and 12. Structures were determined based on spectroscopic analyses. 6- gamma, gamma-Dimethylallyldihydrokaempferol 7- O- beta-D-glucoside (1), 6-gamma, gamma-dimethylallylquercetin 7- O- beta- D-glucoside (3), 6-(3-hydroxy-3-methylbutyl)taxifolin 7- O- beta-D-glucoside (4), 6-(3-hydroxy-3-methylbutyl)quercetin 7- O-beta-D-glucoside (5), and 6-gamma, gamma-dimethylallyltaxifolin 7-O-beta-D-glucoside (11) showed anti-HIV-1 activities in the syncytium assay using the (Delta Tat/rev)MC99 virus and the 1A2 cell line system with EC(50) values ranging from 14.0 - 102.4 microg/mL. Furthermore, ochnaflavone 7''-O-methyl ether (7) and 2'', 3''-dihydroochnaflavone 7''-O-methyl ether (8) were very active; they exerted activities in the syncytium assay with EC(50) values of 2.0 and 0.9 microg/mL, respectively, and likewise inhibited HIV-1 reverse transcriptase (RT) with IC(50) values of 2.0 and 2.4 microg/mL, respectively.

Study Type : In Vitro Study

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Sayer Ji
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