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Article Publish Status: FREE
Abstract Title:

Neuronal Small RNAs Control Behavior Transgenerationally.

Abstract Source:

Cell. 2019 Jun 4. Epub 2019 Jun 4. PMID: 31178120

Abstract Author(s):

Rachel Posner, Itai Antoine Toker, Olga Antonova, Ekaterina Star, Sarit Anava, Eran Azmon, Michael Hendricks, Shahar Bracha, Hila Gingold, Oded Rechavi

Article Affiliation:

Rachel Posner

Abstract:

It is unknown whether the activity of the nervous system can be inherited. In Caenorhabditis elegans nematodes, parental responses can transmit heritable small RNAs that regulate gene expression transgenerationally. In this study, we show that a neuronal process can impact the next generations. Neurons-specific synthesis of RDE-4-dependent small RNAs regulates germline amplified endogenous small interfering RNAs (siRNAs) and germline gene expression for multiple generations. Further, the production of small RNAs in neurons controls the chemotaxis behavior of the progeny for at least three generations via the germline Argonaute HRDE-1. Among the targets of these small RNAs, we identified the conserved gene saeg-2, which is transgenerationally downregulated in the germline. Silencing of saeg-2 following neuronal small RNA biogenesis is required for chemotaxis under stress. Thus, we propose a small-RNA-based mechanism for communication of neuronal processes transgenerationally.

Study Type : Animal Study

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Sayer Ji
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