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Abstract Title:

Anti-fibrotic effects of neferine on carbon tetrachloride-induced hepatic fibrosis in mice.

Abstract Source:

Am J Chin Med. 2015 ;43(2):231-40. Epub 2015 Mar 24. PMID: 25800905

Abstract Author(s):

Mo-Si Chen, Jia-Hua Zhang, Jia-Ling Wang, Lu Gao, Xiao-Xu Chen, Jun-Hua Xiao

Article Affiliation:

Mo-Si Chen

Abstract:

The effects of neferine, a bisbenzylisoquinline alkaloid extracted from the seed embryo of the Chinese traditional medicine Nelumbo nucifera Gaertn, on carbon tetrachloride (CCl4)-induced hepatic fibrosis in mice were evaluated. Adult male Kunming mice were administered with CCl4 1 ml/kg via intraperitoneal injection twice a week for 8 weeks. At the beginning of the 9th week, mice were treated with normal saline, colchicine (0.1 mg/kg), and neferine (5, 10, 20 mg/kg) via intraperitoneal injection once a day for 2 weeks. The liver index and histological examination, plasma ALT/AST levels, hydroxyproline and TGF-β1 content of liver tissue were examined. In the model group, the liver index, the hydroxyproline content of liver tissue and plasma ALT/AST levels were increased, and a high expression of TGF-β1 was observed. The abnormal changes could be improved by neferine in a dose-dependent manner. Our datashowed that neferine had an antifibrosis effect on CCl4-induced hepatic fibrosis in mice, possibly partly due to the decreased expression of TGF-β1 in the liver.

Study Type : Animal Study

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Sayer Ji
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