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Abstract Title:

Antinociceptive and anti-inflammatory effects of the citrus flavanone naringenin.

Abstract Source:

Ci Ji Yi Xue Za Zhi. 2019 Apr-Jun;31(2):81-85. PMID: 31007486

Abstract Author(s):

Ting-Wen Chung, Shiming Li, Chi-Chien Lin, Sen-Wei Tsai

Article Affiliation:

Ting-Wen Chung

Abstract:

Objective: Naringenin, a flavonoid found in citrus fruits, has notably diverse pharmacological properties. In the present study, we investigated the antinociceptive and anti-inflammatory effects of naringenin.

Materials and Methods: The antinociceptive effects were evaluated using hot-plate, acetic acid-induced writhing, and tail-flick assays in mice and rats. The anti-inflammatory effects were examined by a carrageenan-induced paw edema test in rats.

Results: Naringenin (100 or 200 mg/kg, oral administration) significantly delayed the reaction time of mice to thermal stimulation generated by a hot plate and a tail-flick unit and reduced the acetic acid-induced writhing response in mice. In addition, naringenin significantly decreased paw edema induced by carrageenan in rats, showing its anti-inflammatory effect.

Conclusion: Our results show that naringenin has therapeutic potential with antinociceptive and anti-inflammatory properties and can further be exploited for the development of drugs for pain and inflammatory-related diseases.

Study Type : Animal Study

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Sayer Ji
Founder of GreenMedInfo.com

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