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Article Publish Status: FREE
Abstract Title:

Naringenin Prevents Osteosarcoma Progression and Recurrence in the Patients Who Underwent Osteosarcoma Surgery by Improving Antioxidant Capability.

Abstract Source:

Oxid Med Cell Longev. 2018 ;2018:8713263. Epub 2018 Feb 7. PMID: 29576857

Abstract Author(s):

Lirong Zhang, Xiaohua Xu, Tiechao Jiang, Kunzhe Wu, Chuanbo Ding, Zhen Liu, Xuanhe Zhang, Tianhua Yu, Changlong Song

Article Affiliation:

Lirong Zhang

Abstract:

is rich in flavonoids, which may prevent osteosarcoma progression, but its related molecular mechanism remains unclear. Flavonoids were extracted fromand purified by reparative HPLC. Each fraction was identified by using electrospray ionisation mass spectrometry (ESI-MS). Three main components (naringin, naringenin, and hesperetin) were isolated from. Naringenin inhibited the growth of MG-63 cells, whereas naringin and hesperetin had no inhibitory function on cell growth. ROS production was increased in naringin- and hesperetin-treated groups after one day of culture while the level was always lowest in the naringenin-treated group after three days of culture. 95 osteosarcoma patients who underwent surgery were assigned into two groups: naringenin group (NG, received 20 mg naringenin daily,= 47) and control group (CG, received 20 mg placebo daily,= 48). After an average of two-year follow-up, osteosarcoma volumes were smaller in the NG group than in the CG group (>0.01). The rate of osteosarcoma recurrence was also lower in the NG group than in CG group. ROS levels were lower in the NG group than in the CG group. Thus, naringenin frominhibits osteosarcoma progression and local recurrence in the patients who underwent osteosarcoma surgery by improving antioxidant capability.

Study Type : Human Study

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Sayer Ji
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