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Article Publish Status: FREE
Abstract Title:

Cytotoxic effects of fucoidan nanoparticles against osteosarcoma.

Abstract Source:

Mar Drugs. 2013 Oct 30 ;11(11):4267-78. Epub 2013 Oct 30. PMID: 24177673

Abstract Author(s):

Ryuichiro Kimura, Takayoshi Rokkaku, Shinji Takeda, Masachika Senba, Naoki Mori

Article Affiliation:

Ryuichiro Kimura

Abstract:

In this study, we analyzed the size-dependent bioactivities of fucoidan by comparing the cytotoxic effects of native fucoidan and fucoidan lipid nanoparticles on osteosarcoma in vitro and in vivo. In vitro experiments indicated that nanoparticle fucoidan induced apoptosis of an osteosarcoma cell line more efficiently than native fucoidan. The more potent effects of nanoparticle fucoidan, relative to native fucoidan, were confirmed in vivo using a xenograft osteosarcoma model. Caco-2 cell transport studies showed that permeation of nanoparticle fucoidan was higher than native fucoidan. The higher bioactivity and superior bioavailability of nanoparticle fucoidan could potentially be utilized to develop novel therapies for osteosarcoma.

Study Type : In Vitro Study
Additional Links
Pharmacological Actions : Apoptotic : CK(5217) : AC(3846)

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Sayer Ji
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