Nanoliposome improves inhibitory effects of naringenin on nonalcoholic fatty liver disease. - GreenMedInfo Summary
Nanoliposome improves inhibitory effects of naringenin on nonalcoholic fatty liver disease in mice.
Nanomedicine (Lond). 2017 Jul 18. Epub 2017 Jul 18. PMID: 28718703
AIM: To prepare naringenin nanoliposome (NRG-Nanolipo) and investigate its inhibitory effects on nonalcoholic fatty liver disease (NAFLD).
MATERIALS & METHODS: NRG-Nanolipo was prepared by thin-film rehydration method. Its characterizations and effects on NAFLD in mice induced by methionine choline deficient diet were investigated.
RESULTS: NRG-Nanolipo had high-drug loading percentage and showed a sustained release profile. The nanoliposome formulation significantly increased oral absorption of naringenin (NRG). NRG-Nanolipo showed comparable inhibitory effects as NRG crude drug at a dose fourfold lower than the crude drug on NAFLD.
CONCLUSION: It is the first study to report the inhibitory effects of NRG on NAFLD, and the NRG-Nanolipo significantly improved oral absorption of NRG, thus improved liver protective effects of NRG on NAFLD.