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Article Publish Status: FREE
Abstract Title:

Effect of Nigella sativa supplementation on lung function and inflammatory mediatorsin partly controlled asthma: a randomized controlled trial.

Abstract Source:

Ann Saudi Med. 2017 Jan-Feb;37(1):64-71. PMID: 28151459

Abstract Author(s):

Ayad Mohammed Salem, Abdullah Omar Bamosa, Hatem Othman Qutub, Rakesh Kumar Gupta, Ahmed Badar, Abdelsalam Elnour, Muhammad Nasir Afzal

Article Affiliation:

Ayad Mohammed Salem

Abstract:

BACKGROUND: Nigella sativa and its derivatives have been reported to have anti-inflammatory and bronchodilator effects, but the effects have been evaluated in only a few clinical studies.

OBJECTIVES: To determine the effect of N sativa supplementation on inflammation of the airways and limitation of airflow in partly controlled asthma patients.

DESIGN: Single-blind, placebo-controlled, randomized study.

SETTING: Asthma and allergy clinic of a university hospital in eastern Saudi Arabia.

PATIENTS AND METHODS: Patients were divided into three groups. A control group (n=24) received the placebo, while NS-1 and NS-2 groups (n=26 each) received 1 and 2 g/day of N sativa, respectively, for 3 months along with maintenance inhaled therapy.

MAIN OUTCOME MEASURE(S): Asthma control test (ACT) score, fractional exhaled nitric oxide (FeNO), peak expiratory flow (PEF) variability and other pulmonary function tests, IgE, serum cytokines, and frequency of exacerbations.

RESULTS: FEF25-75% and FEV1 (% predicted) increased significantly (P<.05) at both 6 and 12 weeks in the NS-2 group. PEF variability significantly improved in both NS-1 and NS-2 groups at 6 and 12 weeks as compared with the controls (P<.05). FeNO and serum IgE decreased significantly after 12 weeks in both the NS-1 and NS-2 groups vs baseline (P<.05). Both doses of N sativa produced a significant increase in the serum IFN-gamma at 12 weeks vs baseline (P<.05) as well as a significant improvement in the ACT score at 6 and 12 weeks vs baseline (P<.001,<.01). Significantly fewer patients had exacerbations in the NS-1 group (P<.05).

CONCLUSION: N sativa supplementation with inhaled maintenance therapy improves some measures of pulmonary function and inflammation in partly controlled asthma.

LIMITATIONS: No bronchoalveolar lavage or sputum samples taken for measurement of asthma markers. ISRCTN registry: ISRCTN48853858 DOI 10.1186/ISRCTN48853858.

Study Type : Human Study

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