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Abstract Title:

Myricetin suppresses UVB-induced wrinkle formation and MMP-9 expression by inhibiting Raf.

Abstract Source:

Phytother Res. 2008 Mar;22(3):323-9. PMID: 20093107

Abstract Author(s):

Sung Keun Jung, Ki Won Lee, Ho Young Kim, Mi Hyun Oh, Sanguine Byun, Sung Hwan Lim, Yong-Seok Heo, Nam Joo Kang, Ann M Bode, Zigang Dong, Hyong Joo Lee

Article Affiliation:

Major in Biomodulation, Department of Agricultural Biotechnology, Seoul National University, Seoul 151-921, Republic of Korea; The Hormel Institute, University of Minnesota, MN 55912, USA; Department of Bioscience and Biotechnology, Bio/Molecular Informatics Center, Konkuk University, Seoul 143-701, Republic of Korea.

Abstract:

Chronic exposure to solar ultraviolet (UV) light causes skin photoaging. Many studies have shown that naturally occurring phytochemicals have anti-photoaging effects, but their direct target molecule(s) and mechanism(s) remain unclear. We found that myricetin, a major flavonoid in berries and red wine, inhibited wrinkle formation in mouse skin induced by chronic UVB irradiation (0.18J/cm(2), 3 days/week for 15 weeks). Myricetin treatment reduced UVB-induced epidermal thickening of mouse skin and also suppressed UVB-induced matrix metalloproteinase-9 (MMP-9) protein expression and enzyme activity. Myricetin appeared to exert its anti-aging effects by suppressing UVB-induced Raf kinase activity and subsequent attenuation of UVB-induced phosphorylation of MEK and ERK in mouse skin. In vitro and in vivo pull-down assays revealed that myricetin bound with Raf in an ATP-noncompetitive manner. Overall, these results indicate that myricetin exerts potent anti-photoaging activity by regulating MMP-9 expression through the suppression of Raf kinase activity.

Study Type : Animal Study

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Sayer Ji
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