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Article Publish Status: FREE
Abstract Title:

Dietary compounds galangin and myricetin suppress ovarian cancer cell angiogenesis.

Abstract Source:

J Funct Foods. 2015 May 1 ;15:464-475. PMID: 26113875

Abstract Author(s):

Haizhi Huang, Allen Y Chen, Yon Rojanasakul, Xingqian Ye, Gary O Rankin, Yi Charlie Chen

Article Affiliation:

Haizhi Huang

Abstract:

Galangin and myricetin are flavonoids isolated from vegetables and fruits which exhibit anti-proliferative activity in human cancer cells. In this study, their anti-angiogenic effects were investigated with(HUVEC) and(CAM) models, which showed that galangin and myricetin inhibited angiogenesis induced by OVCAR-3 cells. The molecular mechanisms through which galangin and myricetin suppress angiogenesis were also studied. It was observed that galangin and myricetin inhibited secretion of the key angiogenesis mediator vascular endothelial growth factor (VEGF) and decreased levels of p-Akt, p-70S6K and hypoxia-inducible factor-1α (HIF-1α) proteins in A2780/CP70 and OVCAR-3 cells. Transient transfection experiments showed that galangin and myricetin inhibited secretion of VEGF by the Akt/p70S6K/ HIF-1α pathway. Moreover, a novel pathway, p21/HIF-1α/VEGF, was found to be involved in the inhibitory effect of myricetin onangiogenesis in OVCAR-3 cells. These data suggest that galangin and myricetin might serve as potential anti-angiogenic agents in the prevention of ovarian cancers dependent on new blood vessel networks.

Study Type : Animal Study, In Vitro Study

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