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Abstract Title:

Anti-ulcer and ulcer healing potentials of Musa sapientum peel extract in the laboratory rodents.

Abstract Source:

Pharmacognosy Res. 2013 Jul ;5(3):173-8. PMID: 23900937

Abstract Author(s):

Samuel Adetunji Onasanwo, Benjamin Obukowho Emikpe, Austin Azubuike Ajah, Taiwo Olayemi Elufioye

Article Affiliation:

Samuel Adetunji Onasanwo

Abstract:

BACKGROUND: This study investigated the anti-ulcer and ulcer healing potentials of the methanol extract of Musa sapientum peel in the laboratory rats.

MATERIALS AND METHODS: Methanol extract of the peels on Musa sapientum (MEMS) was evaluated for its anti-ulcer using alcohol-induced, aspirin-induced, and pyloric ligation-induced models, and for its ulcer healing employing acetic acid-induced ulcer models in rats.

RESULTS: The findings from this experiment showed that MEMS (50, 100 and 200 mg/kg, b.w.) anti-ulcer and ulcer healing activity (P≤ 0.05) is dose-dependent. Also, MEMS exhibited healing of the ulcer base in all the treated groups when compared with the control group.

CONCLUSION: The outcomes of this experiment revealed that the anti-ulcer effect of MEMS may be due to its anti-secretory and cyto-protective activity. The healing of the ulcer base might not be unconnected with basic fibroblast growth factors responsible for epithelial regeneration.

Study Type : Animal Study
Additional Links
Pharmacological Actions : Anti-Ulcer Agents : CK(390) : AC(140)

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Sayer Ji
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