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Abstract Title:

Effect of Leonurus cardiaca oil extract in patients with arterial hypertension accompanied by anxiety and sleep disorders.

Abstract Source:

Phytother Res. 2011 Apr;25(4):540-3. Epub 2010 Sep 13. PMID: 20839214

Abstract Author(s):

Alexander N Shikov, Olga N Pozharitskaya, Valery G Makarov, Dmitry V Demchenko, Evgenia V Shikh

Article Affiliation:

Saint-Petersburg Institute of Pharmacy, 47/5, Piskarevsky pr., 195067, St Petersburg, Russia. alexs79@mail.ru.

Abstract:

Leonurus cardiaca L. (Lamiaceae) is used traditionally for its sedative, hypotensive and cardiotonic effects. Due to the lack of clinical data regarding its effect in patients, a study was carried out to assess the clinical efficacy of Leonurus oil extract (LOE) in patients with arterial hypertension stages 1 and 2, accompanied by anxiety and sleep disorders. Fifty patients were treated for 28 days with 1200 mg LOE per day. Positive effects of LOE on psycho-emotional status and arterial blood pressure in patients with stage 1 hypertension were observed 1 week earlier than in patients with stage 2 hypertension. According to the Clinical Global Impression (CGI) scale, a significant improvement in the symptoms of anxiety and depression was observed in 32% of patients, a moderate improvement in 48% and a weak effect in 8%; 12% of patients did not respond to therapy. Side effects were minimal in all groups. Leonurus oil extract may therefore be a potentially effective therapeutic agent for patientswith arterial hypertension and concurrent psycho-neurological disorders. Copyright © 2010 John Wiley&Sons, Ltd.

Study Type : Human Study

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Sayer Ji
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