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Article Publish Status: FREE
Abstract Title:

Mangiferin and Morin Attenuate Oxidative Stress, Mitochondrial Dysfunction, and Neurocytotoxicity, Induced by Amyloid Beta Oligomers.

Abstract Source:

Oxid Med Cell Longev. 2018 ;2018:2856063. Epub 2018 Jun 14. PMID: 30013719

Abstract Author(s):

Elena Alberdi, María Victoria Sánchez-Gómez, Asier Ruiz, Fabio Cavaliere, Carolina Ortiz-Sanz, Tania Quintela-López, Estibaliz Capetillo-Zarate, Santiago Solé-Domènech, Carlos Matute

Article Affiliation:

Elena Alberdi

Abstract:

Amyloid beta- (A-) mediated ROS overproduction disrupts intraneuronal redox balance and exacerbates mitochondrial dysfunction which leads to neuronal injury. Polyphenols have been investigated as therapeutic agents that promote neuroprotective effects in experimental models of brain injury and neurodegenerative diseases. The aim of this study was to identify the neuroprotective effects of morin and mangiferin against Aoligomers in cultured cortical neurons and organotypic slices as well as their mechanisms of action. Cell death caused by Aoligomers in neuronal cultures was decreased in the presence of micromolar concentrations of mangiferin or morin, which in turn attenuated oxidative stress. The neuroprotective effects of antioxidants against Awere associated with the reduction of A-induced calcium load to mitochondria; mitochondrial membrane depolarization; and release of cytochrome c from mitochondria, a key trigger of apoptosis. Additionally, we observed that both polyphenols activated the endogenous enzymatic antioxidant system and restored oxidized protein levels. Finally, Ainduced an impairment of energy homeostasis due to a decreased respiratory capacity that was mitigated by morin and mangiferin. Overall, the beneficial effects of polyphenols in preventing mitochondrial dysfunction and neuronal injury in AD cell models suggest that morin and mangiferin hold promise for the treatment of this neurological disorder.

Study Type : In Vitro Study

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