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Abstract Title:

Monoterpene derivatives from the roots of Paeonia lactiflora and their anti-proliferative activity.

Abstract Source:

Fitoterapia. 2014 Oct ;98:124-9. Epub 2014 Jul 25. PMID: 25068201

Abstract Author(s):

Pan Li, Ze-Ming Zhang, Tao Li, Yan-Bo Zhang, Stephen Cho Wing Sze, Guo-Cai Wang, Yao-Lan Li, Wen-Cai Ye

Article Affiliation:

Pan Li

Abstract:

An unusual nor-monoterpene with only nine carbons, nor-paeonilactone (1), two new monoterpenes, paeonisuffrone C (2), paeonilactone D (9), and a new monoterpene glucoside, paeonin D (3), along with ten known compounds were isolated from the dried roots of Paeonia lactiflora. Their structures were elucidated on the basis of spectroscopic analysis, including 1D and 2D NMR, and computational data. Compounds 4-14 were evaluated for their anti-proliferative activities against BT 483 human breast cancer cells and OVCA 429 human ovarian cancer cells by MTT assay.

Study Type : In Vitro Study
Additional Links
Pharmacological Actions : Antiproliferative : CK(4773) : AC(3450)

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Sayer Ji
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