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Abstract Title:

MicroRNA targeting by quercetin in cancer treatment and chemoprotection.

Abstract Source:

Pharmacol Res. 2019 Jul 8:104346. Epub 2019 Jul 8. PMID: 31295570

Abstract Author(s):

Doo Hwan Kim, Haroon Khan, Hammad Ullah, Sherif T S Hassan, Karel Šmejkal, Thomas Efferth, Mohamad Fawzi Mahamoodally, Suowen Xu, Solomon Habtemariam, Rosanna Filosa, Ricardo Lagoa, Kannan Rr Rengasamy

Article Affiliation:

Doo Hwan Kim

Abstract:

A growing number of evidences from clinical and preclinical studies have shown that dysregulation of microRNA (miRNA) function contributes to the progression of cancer and thus miRNA can be an effective target in therapy. Dietary phytochemicals, such as quercetin, are natural products that have potential anti-cancer properties due to their proven antioxidant, anti-inflammatory, and anti-proliferative effects. Available experimental studies indicate that quercetin could modulate multiple cancer-relevant miRNAs including let-7, miR-21, miR-146a and miR-155, thereby inhibiting cancer initiation and development. This paper reviews the data supporting the use of quercetin for miRNA-mediated chemopreventive and therapeutic strategies in various cancers, with the aim to comprehensively understand its health-promoting benefits and pharmacological potential. Integration of technology platforms for miRNAs biomarker and drug discovery is also presented.

Study Type : Review

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Sayer Ji
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