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Abstract Title:

Protective effect of methylsulfonylmethane in caerulein-induced acute pancreatitis and associated lung injury in mice.

Abstract Source:

J Pharm Pharmacol. 2018 Sep ;70(9):1188-1199. Epub 2018 Jul 3. PMID: 29971769

Abstract Author(s):

Ranjith Kumar Velusamy, Ramasamy Tamizhselvi

Article Affiliation:

Ranjith Kumar Velusamy

Abstract:

OBJECTIVES: In the present study, we have elaborated the anti-inflammatory mechanism of MSM through homing of CD34stem cells towards an inflamed region by regulating hydrogen sulfide (HS) in an in vivo model of caerulein-induced acute pancreatitis (AP) and associated lung injury.

METHODS: Male Swiss mice were treated with hourly intraperitoneal injections of caerulein (50μg/kg) for 6 h. MSM (500 mg/kg) was administered intraperitoneally 1 h after the first caerulein injection (therapeutic). The serum amylase activity and myeloperoxidase (MPO) activity in lung and pancreas were measured. The levels of HS and interleukin (IL)-1β, cystathionine-γ-lyase (CSE) and CD34expressions in pancreas and lungs were determined by RT-PCR and ELISA.

KEY FINDINGS: Methylsulfonylmethane significantly ameliorated pancreas and lung histopathological changes, decreased serum amylase, MPO activity and inhibited caerulein-induced IL-1β expression. Furthermore, MSM reduced caerulein-induced HS levels by alleviating the expression of CSE in pancreas and lungs and increased CD34 expression and inhibited nuclear factor (NF)-κB translocation in caerulein-induced AP and associated lung injury.

CONCLUSIONS: These findings indicate that MSM can effectively reduce inflammatory responses and induce the homing of CD34cells to the injured tissues.

Study Type : Animal Study

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