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Article Publish Status: FREE
Abstract Title:

Neurite outgrowth-promoting active constituents of the Japanese cypress (Chamaecyparis obtusa).

Abstract Source:

Chem Pharm Bull (Tokyo). 2008 Jan ;56(1):60-3. PMID: 18175976

Abstract Author(s):

Masanori Kuroyanagi, Ryuya Ikeda, Hui Yuan Gao, Norio Muto, Keisuke Otaki, Toshikazu Sano, Nobuo Kawahara, Takahisa Nakane

Article Affiliation:

Masanori Kuroyanagi

Abstract:

In the screening of biologically active constituents from woody plants, the methanol extract of leaves of Chamaecyparis obtusa showed potent neurite outgrowth-promoting activity in neuronal PC12 cells. The ethyl acetate-soluble fraction of the methanol extract showed potent activity and was separated by means of various chromatographic methods to give the two new compounds 1 and 2, as well as 11 known lignan and sesquiterpene derivatives. The structures of the new compounds were determined to be 9-O-acetyldihydrosesamin (1) and 9-O-(11-hydroxyeudesman-4-yl)dihydrosesamin (2), respectively, in NMR studies including 2D-NMR experiments. Of the 13 compounds, the known compound hinokinin (5) and the new compound 2 showed potent neurite outgrowth-promoting activity in PC 12 cells.

Study Type : In Vitro Study
Additional Links
Pharmacological Actions : Neuritogenic : CK(133) : AC(59)

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Sayer Ji
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