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Abstract Title:

Curcumin downregulates human tumor necrosis factor-α levels: A systematic review and meta-analysis ofrandomized controlled trials.

Abstract Source:

Pharmacol Res. 2016 Mar 26 ;107:234-242. Epub 2016 Mar 26. PMID: 27025786

Abstract Author(s):

Amirhossein Sahebkar, Arrigo F G Cicero, Luis E Simental-Mendía, Bharat B Aggarwal, Subash C Gupta

Article Affiliation:

Amirhossein Sahebkar

Abstract:

BACKGROUND: Tumor necrosis factor-α (TNF-α) is a key inflammatory mediator and its reduction is a therapeutic target in several inflammatory diseases. Curcumin, a bioactive polyphenol from turmeric, has been shown in several preclinical studies to block TNF-α effectively. However, clinical evidence has not been fully conclusive.

OBJECTIVE: The aim of the present meta-analysis was to evaluate the efficacy of curcumin supplementation on circulating levels of TNF-α in randomized controlled trials (RCTs).

METHODS: The search included PubMed-Medline, Scopus, Web of Science and Google Scholar databases by up to September 21, 2015, to identify RCTs investigating the impact of curcumin on circulating TNF-α concentration. Quantitative data synthesis was performed using a random-effects model, with weighed mean difference (WMD) and 95% confidence interval (CI) as summary statistics. Meta-regression and leave-one-out sensitivity analyses were performed to assess the modifiers of treatment response.

RESULTS: Eight RCTs comprising nine treatment arms were finally selected for the meta-analysis. There was a significant reduction of circulating TNF-α concentrations following curcumin supplementation (WMD: -4.69pg/mL, 95% CI: -7.10, -2.28, p<0.001). This effect size was robust in sensitivity analysis. Meta-regression did not suggest any significant association between the circulating TNF-α-lowering effects of curcumin with either dose or duration (slope: 0.197; 95% CI: -1.73, 2.12; p=0.841) of treatment.

CONCLUSION: This meta-analysis of RCTs suggested a significant effect of curcumin in lowering circulating TNF-α concentration.

Study Type : Meta Analysis

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Sayer Ji
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