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Article Publish Status: FREE
Abstract Title:

Mangiferin and Cancer: Mechanisms of Action.

Abstract Source:

Nutrients. 2016 ;8(7). Epub 2016 Jun 28. PMID: 27367721

Abstract Author(s):

Fuchsia Gold-Smith, Alyssa Fernandez, Karen Bishop

Article Affiliation:

Fuchsia Gold-Smith

Abstract:

Mangiferin, a bioactive compound derived primarily from Anacardiaceae and Gentianaceae families and found in mangoes and honeybush tea, has been extensively studied for its therapeutic properties. Mangiferin has shown promising chemotherapeutic and chemopreventative potential. This review focuses on the effect of mangiferin on: (1) inflammation, with respect to NFκB, PPARү and the immune system; (2) cell cycle, the MAPK pathway G₂/M checkpoint; (3) proliferation and metastasis, and implications on β-catenin, MMPs, EMT, angiogenesis and tumour volume; (4) apoptosis, with a focus on Bax/Bcl ratios, intrinsic/extrinsic apoptotic pathways and telomerase activity; (5) oxidative stress, through Nrf2/ARE signalling, ROS elimination and catalase activity; and (6) efficacy of chemotherapeutic agents, such as oxaliplatin, etoposide and doxorubicin. In addition, the need to enhance the bioavailability and delivery of mangiferin are briefly addressed, as wellas the potential for toxicity.

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Sayer Ji
Founder of GreenMedInfo.com

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