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Abstract Title:

Dietary magnesium deficiency affects gut microbiota and anxiety-like behaviour in C57BL/6N mice.

Abstract Source:

Acta Neuropsychiatr. 2015 Mar 16:1-5. Epub 2015 Mar 16. PMID: 25773775

Abstract Author(s):

Bettina Pyndt Jørgensen, Gudrun Winther, Pernille Kihl, Dennis S Nielsen, Gregers Wegener, Axel K Hansen, Dorte B Sørensen

Article Affiliation:

Bettina Pyndt Jørgensen

Abstract:

OBJECTIVE: Magnesium deficiency has been associated with anxiety in humans, and rodent studies have demonstrated the gut microbiota to impact behaviour.

METHODS: We investigated the impact of 6 weeks of dietary magnesium deficiency on gut microbiota composition and anxiety-like behaviour and whether there was a link between the two. A total of 20 C57BL/6 mice, fed either a standard diet or a magnesium-deficient diet for 6 weeks, were tested using the light-dark box anxiety test. Gut microbiota composition was analysed by denaturation gradient gel electrophoresis.

RESULTS: We demonstrated that the gut microbiota composition correlated significantly with the behaviour of dietary unchallenged mice. A magnesium-deficient diet altered the gut microbiota, and was associated with altered anxiety-like behaviour, measured by decreased latency to enter the light box.

CONCLUSION: Magnesium deficiency altered behavior. The duration of magnesium deficiency is suggested to influence behaviour in the evaluated test.

Study Type : Animal Study

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Sayer Ji
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