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Abstract Title:

The hypolipidemic effect and antithrombotic activity of Mucuna pruriens protein hydrolysates.

Abstract Source:

Food Funct. 2016 Jan ;7(1):434-44. PMID: 26505152

Abstract Author(s):

Francisco Herrera Chalé, Jorge Carlos Ruiz Ruiz, David Betancur Ancona, Juan José Acevedo Fernández, Maira Rubi Segura Campos

Article Affiliation:

Francisco Herrera Chalé

Abstract:

Hydrolysates and peptide fractions (PF) obtained from M. pruriens protein concentrates with commercial and digestive enzymatic systems were studied for their hypolipidemic and antithrombotic activities. Hydrolysates obtained with Pepsin-Pancreatin (PP) and their peptide fractions inhibited cholesterol micellar solubility with a maximum value of 1.83% in PP. Wistar rats were used to evaluate the hypolipidemic effect of hydrolysates and PF. The higher reductions of cholesterol and triglyceride levels were exhibited by PP and both peptide fractions<1 kDa obtained from PP and Alcalase®-Flavourzyme® hydrolysate (AF) at a dose of 15 mg kg(-1) of animal weight. PF>10 kDa from both hydrolysates showed the maximum antithrombotic activity with values of 33.33% for PF>10 kDa from AF and 31.72% for PF>10 kDa from PP. The results suggest that M. pruriens bioactive peptides with the hypolipidemic effect and antithrombotic activity might be utilized as nutraceuticals.

Study Type : Animal Study

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Sayer Ji
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