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Abstract Title:

Effects of Luteolin and Quercetin in Combination with Some Conventional Antibiotics against Methicillin-Resistant Staphylococcus aureus.

Abstract Source:

Int J Mol Sci. 2016 Nov 22 ;17(11). Epub 2016 Nov 22. PMID: 27879665

Abstract Author(s):

Muhammad Usman Amin, Muhammad Khurram, Taj Ali Khan, Hani S Faidah, Zia Ullah Shah, Shafiq Ur Rahman, Abdul Haseeb, Muhammad Ilyas, Naseem Ullah, Sahibzada Muhammad Umar Khayam, Marcello Iriti

Article Affiliation:

Muhammad Usman Amin

Abstract:

The present study was designed to evaluate the effects of flavonoids luteolin (L) and quercetin + luteolin (Q + L) in combination with commonly used antibacterial agents against methicillin-resistant Staphylococcus aureus (MRSA) clinical isolates and S. aureus (ATCC 43300). Minimum inhibitory concentrations (MICs) of L and Q + L, as well as the MICs of flavonoids in combination with antibiotics were determined and results showed an increased activity of flavonoids with antibiotics. The synergistic, additive, or antagonistic relationships between flavonoids (L and Q + L) and antibiotics were also evaluated, and additive and synergistic effects were observed for some antibiotic + flavonoid combinations. In addition, some combinations were also found to damage the bacterial cytoplasmic membrane, as assessed through potassium leakage assay. The effects of flavonoids and flavonoids + antibiotics on mecA gene mutations were also tested, and no functional variation was detected in the coding region.

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Sayer Ji
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