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Abstract Title:

Investigation of the anxiolytic effects of luteolin, a lemon balm flavonoid in the male Sprague-Dawley rat.

Abstract Source:

AANA J. 2009 Feb;77(1):33-6. PMID: 19263826

Abstract Author(s):

Terry Raines, Paul Jones, Naomie Moe, Robert Duncan, Suzanne McCall, Thomas E Ceremuga

Article Affiliation:

US Army Graduate Program in Anesthesia Nursing, Fort Sam Houston, Texas, USA.

Abstract:

The purpose of this study was to investigate the anxiolytic effects of luteolin and its potential interaction with the gamma-aminobutyric acid (GABAA) receptor in male Sprague-Dawley rats. Lemon balm has traditionally been used as an herbal remedy in the treatment of many medical conditions, including anxiety. Luteolin is a major component of the essential oil lemon balm. We divided 55 rats into 5 groups: (1) control (negative control), (2) luteolin, (3) midazolam (positive control), (4) flumazenil and luteolin, and (5) midazolam and luteolin. The behavioral component of anxiety was examined by using the elevated plus-maze (open arm time/total time) and motor movements. Data analyses were performed using a 2-tailed multivariate analysis of variance and Sheffé post hoc test. Our data suggest that luteolin does not produce anxiolysis by modulation of the GABAA receptor; however, luteolin may modulate motor movements and locomotion.

Study Type : Animal Study

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Sayer Ji
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