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Abstract Title:

Structural alterations of human immortal astrocytes after inhibition of 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase by lovastatin.

Abstract Source:

J Submicrosc Cytol Pathol. 1995 Oct ;27(4):435-44. PMID: 7585443

Abstract Author(s):

Y V Bobryshev, O V Pavlov, Y V Balabanov, K Ashwell

Article Affiliation:

Institute of the Human Brain, St Petersburg, Russia.

Abstract:

This investigation was designed to study the specific structural alterations of astroglial cells following the inhibition of 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase, which is a key enzyme in cholesterol synthesis. In our previous investigations, it has been demonstrated that lovastatin, which is a specific competitive inhibitor of 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase, effectively inhibited cholesterol synthesis in human primary and immortal astrocytes in serum and lipid-free media, and we also showed that the effects on both astrocytes of primary cultures and immortal astrocytes (ASCh-7) were very similar. In the present study we therefore examined effects of lovastatin at a concentration of 100 ng/ml on human immortal astrocytes (ASCh-7) using electron microscopic analysis. We have found that lovastatin significantly affects human immortal astrocytes, resulting in degenerative ultrastructural changes including accumulation of a large number of phagosomes, oedema of the cytoplasm and destruction of gliofilaments. The results obtained suggest that the human immortal astrocyte cell line (ASCh-7) can be not only very useful for screening drugs in pharmacological research but can also provide a useful model for examining fine structural alterations of cells following selective disturbances of metabolism.

Study Type : In Vitro Study

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Sayer Ji
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