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Abstract Title:

Long-term exposure of 2450 MHz electromagnetic radiation induces stress and anxiety like behavior in rats.

Abstract Source:

Neurochem Int. 2019 Sep ;128:1-13. Epub 2019 Apr 4. PMID: 30954502

Abstract Author(s):

Sukesh Kumar Gupta, Shishir Kumar Patel, Munendra Singh Tomar, Shio Kumar Singh, Manoj Kumar Mesharam, Sairam Krishnamurthy

Article Affiliation:

Sukesh Kumar Gupta

Abstract:

Long term exposure of electromagnetic radiations (EMR) from cell phones and Wi-Fi hold greater propensity to cause anxiety disorders. However, the studies investigating the effects of repeated exposure of EMR are limited. Therefore, we investigated the effects of repeated exposure of discrete frequencies of EMR in experimental animals. Male rats were exposed to EMR (900, 1800 and 2450 MHz) for 28 (1 h/day) days. Long term exposure of EMR (2450 MHz) induced anxiety like behavior. It deregulated the hypothalamic pituitary adrenal (HPA) axis in rats as observed by increase in plasma corticosterone levels apart from decreased corticotrophin releasing hormone-2 (CRH-2) and Glucocorticoid receptor (GR) expression in amygdala. Further, it impaired mitochondrial function and integrity. The expression of Bclshowed significant decrease while Bax and ratio of Bax: Bclwere increased in the mitochondria and vice versa in cytoplasm indicating altered regulation of apoptosis. EMR exposure caused release of cytochrome-c and expression of caspase-9 ensuing activation of apoptotic cell death. Additional set of experiments performed to estimate the pattern of cell death showed necrotic and apoptotic amygdalar cell death after EMR exposure. Histopathological studies also revealed a significant decrease in neuronal cells in amygdala. The above findings indicate that long-term exposure of EMR radiation (2450 MHz) acts as a stressor and induces anxiety-like behaviors with concomitant pathophysiological changes in EMR subjected rats.

Study Type : Animal Study

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