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Abstract Title:

Hericium erinaceus enhances doxorubicin-induced apoptosis in human hepatocellular carcinoma cells.

Abstract Source:

Cancer Lett. 2010 Nov 28 ;297(2):144-54. PMID: 20554107

Abstract Author(s):

Jong Seok Lee, Eock Kee Hong

Article Affiliation:

Department of Bioengineering and Technology, Kangwon National University, Chuncheon 200-701, Republic of Korea.

Abstract:

It has been demonstrated that the Hericium erinaceus (HE) mushroom, which primarily consists of polysaccharides, possesses anti-tumor activities. However, the mechanisms by which HE inhibits human hepatocellular carcinoma growth remain unknown. Our study demonstrates that HE acts as an enhancer to sensitize doxorubicin (Dox)-mediated apoptotic signaling, and this sensitization can be achieved by reducing c-FLIP expression via JNK activation and enhancing intracellular Dox accumulation via the inhibition of NF-κB activity. These findings suggest that HE in combination with Dox serves as an effective tool for treating drug-resistant human hepatocellular carcinoma.

Study Type : In Vitro Study

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