Lignans from the seeds of Chinese hawthorn against β-amyloid aggregation. - GreenMedInfo Summary
Lignans from the seeds of Chinese hawthorn (Crataegus pinnatifida var. major N.E.Br.) againstβ-amyloid aggregation.
Nat Prod Res. 2018 Jul ;32(14):1706-1713. Epub 2017 Nov 8. PMID: 29115158
Phytochemical investigation on the seeds of hawthorn (Crataegus spp.) led to the isolation of a new compound, (7'R, 8'R, 8S)-isolariciresinol (1), along with six known compounds (2-7). The structures of all compounds were determined based on spectroscopic data interpretation. The Aβinhibition activity of all isolated compounds was evaluated in vitro. As a result, compounds 5 and 6 showed stronger inhibition of Aβaggregation than curcumin, with inhibition rates of 70.59 and 68.14% at 20 μM. The possible mechanism of interaction between Aβand the active compounds 5 and 6 was also investigated by molecular docking.