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Article Publish Status: FREE
Abstract Title:

Effect of LavenderEssential Oil on Acute Inflammatory Response.

Abstract Source:

Evid Based Complement Alternat Med. 2018 ;2018:1413940. Epub 2018 Mar 18. PMID: 29743918

Abstract Author(s):

Gabriel Fernando Esteves Cardia, Saulo Euclides Silva-Filho, Expedito Leite Silva, Nancy Sayuri Uchida, Heitor Augusto Otaviano Cavalcante, Larissa Laila Cassarotti, Valter Eduardo Cocco Salvadego, Ricardo Alexandre Spironello, Ciomar Aparecida Bersani-Amado, Roberto Kenji Nakamura Cuman

Article Affiliation:

Gabriel Fernando Esteves Cardia

Abstract:

is a plant of Lamiaceae family, with many therapeutic properties and biological activities, such as anticonvulsant, anxiolytic, antioxidant, anti-inflammatory, and antimicrobial activities. The aim of this study was to evaluate the effect ofMill. essential oil (LEO) on acute inflammatory response. LEO was analyzed using gas chromatography-mass spectrometry (GC-MS) and nuclear magnetic resonance spectroscopy (NMR) methods and showed predominance of 1,8-cineole (39.83%), borneol (22.63%), and camphor (22.12%). LEO at concentrations of 0.5, 1, 3, and 10 g/ml did not presentcytotoxicity. Additionally, LEO did not stimulate the leukocyte chemotaxis. The LEO topical application at concentrations of 0.25, 0.5, and 1 mg/ear reduced edema formation, myeloperoxidase (MPO) activity, and nitric oxide (NO) production in croton oil-induced ear edema model. In carrageenan-induced paw edema model, LEO treatment at doses of 75, 100, and 250 mg/kg reduced edema formation, MPO activity, and NO production. In dextran-induced paw edema model, LEO at doses of 75 and 100 mg/kg reduced paw edema and MPO activity. In conclusion, LEO presented anti-inflammatory activity, and the mechanism proposed of LEO seems to be, at least in part, involving the participation of prostanoids, NO, proinflammatory cytokines, and histamine.

Study Type : In Vitro Study

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Sayer Ji
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