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Abstract Title:

Inhibitory effects of lapachol derivatives on epstein-barr virus activation.

Abstract Source:

Bioorg Med Chem. 2003 Feb 20;11(4):483-8. PMID: 12538012

Abstract Author(s):

Elisa Pérez Sacau, Ana Estévez-Braun, Angel G Ravelo, Esteban A Ferro, Harunkuni Tokuda, Teruo Mukainaka, Hoyoku Nishino

Abstract:

Sixteen derivatives (2-17) synthesized from the naphthoquinone lapachol (1), were tested for their inhibitory effects on Epstein-Barr virus early antigen (EBV-EA) activation induced by 12-O-tetradecanoylphorbol-13-acetate (TPA), as a test for potential cancer chemopreventive agents. They exhibited a variety of inhibitory activities from very high to moderate, which allow us to suggest structure-activity relationships. Ten of these derivatives are reported for the first time, their structures being thoroughly determined by spectroscopic methods.

Study Type : In Vitro Study

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Sayer Ji
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