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Abstract Title:

Lactobacillus rhamnosus GG microcapsules inhibit Escherichia coli biofilm formation in coculture.

Abstract Source:

Biotechnol Lett. 2019 May 30. Epub 2019 May 30. PMID: 31147809

Abstract Author(s):

Huiyi Song, Jianbin Zhang, Jialin Qu, Jianjun Liu, Peiyuan Yin, Guixin Zhang, Dong Shang

Article Affiliation:

Huiyi Song

Abstract:

OBJECTIVES: Microbial biofilms have become one of the most significant causes of nosocomial infections. The aim of this study was to examine the potential quorum sensing inhibitor activities of Lactobacillus rhamnosus GG microcapsules.

RESULTS: Lactobacillus rhamnosus GG microcapsules effectively inhibited initial biofilm formation at a concentration of 2.5 × 10 CFU/mL. Furthermore, the inhibition rate was increased to 79% in the Lactobacillus rhamnosus GG microcapsules group, resulting in a reduction in the biofilm maturation stage. In addition, real-time PCR analysis revealed that the LGG microcapsules can act as effective inhibitors of transcriptionalactivators of the quorum sensing circuit in E.coli, luxS, lsrK, and lsrR.

CONCLUSIONS: Lactobacillus rhamnosus GG microcapsules can effectively inhibit biofilm formation and disturb mature biofilms.

Study Type : In Vitro Study

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