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Abstract Title:

Fermentation of purple Jerusalem artichoke extract to improve theα-glucosidase inhibitory effect in vitro and ameliorate blood glucose in db/db mice.

Abstract Source:

Nutr Res Pract. 2016 Jun ;10(3):282-7. Epub 2016 Mar 2. PMID: 27247724

Abstract Author(s):

Zhiqiang Wang, Seung Hwan Hwang, Sun Youb Lee, Soon Sung Lim

Article Affiliation:

Zhiqiang Wang

Abstract:

BACKGROUND/OBJECTIVES: Jerusalem artichoke has inhibitory activity againstα-glucosidase and decreases fasting serum glucose levels, which may be related to its fructan content. The biological activity of fructan can be influenced by the degree of polymerization. Thus, in this study, the inhibitory effects of original and fermented purple Jerusalem artichoke (PJA) on α-glucosidase were compared in vitro. Additionally, the anti-diabetes effect of Lactobacillus plantarum-fermented PJA (LJA) was studied in a non-insulin-dependent diabetes mellitus animal model (C57BIKsJ db/db).

MATERIALS/METHODS: The water extract of PJA was fermented by L. plantarum, and two strains of Bacillus subtilis to compare their anti-α-glucosidase activities in vitro by α-glucosidase assays. The anti-diabetes effect of LJA was studied in a non-insulin-dependent diabetes mellitus animal model (C57BIKsJ db/db) for seven weeks. During the experiment, food intake, body weight, and fasting blood glucose were measured every week. Atthe end of the treatment period, several diabetic parameters and the intestinal α-glucosidase activity were measured.

RESULTS: The LJA showed the highestα-glucosidase inhibitory activity in vitro. In the in vivo study, it resulted in a significantly lower blood glucose concentration than the control. Serum insulin and HDL cholesterol levels were significantly higher and the concentrations of triglycerides, non-esterified fatty acids, and total cholesterol were significant lower in mice treated with LJA after seven weeks. In addition, the intestinal α-glucosidase activity was partially inhibited.

CONCLUSIONS: These results suggested that LJA regulates blood glucose and has potential use as a dietary supplement.

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Sayer Ji
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