Modulation of intestinal barrier function to ameliorate Salmonella infection in mice by oral administration of fermented milks produced with Lactobacillus plantarum MTCC 5690 - a probiotic strain of Indian gut origin.
J Med Microbiol. 2016 Oct 17. Epub 2016 Oct 17. PMID: 27902414
Probiotic Lactobacillus plantarum MTCC 5690 -a probiotic strain of Indian gut origin as such and milk formulations produced with the same were explored in this sudy as biotherapeutics by evauating their functional efficacy against Salmonella infection in mice. The efficacy of milk formulations (fermented/unfermented) of MTCC 5690 for enhancement of intestinal barrier function was determined by monitoring the permeability and histopathology of intestine. The mice fed with probiotic Dahi (PD), Fermented Probiotic Drink (FD) and Sweetened fermented probiotic drink (SFD) maintained the health and integrity of intestinal epithelium in the infected mice as compared to those fed with phosphate buffered saline, milk, unfermented probiotic milk and Dahi. Our relative expression data revealed that the changes caused by MTCC 5690 in intestinal barrier function components were established through modulation of the key regulatory receptors TLR2 and TLR4. The results suggest that fermented milks of MTCC 5690 could enhance the strengthening of intestinal barrier in enteric infection condition and therefore, can be explored as a dietary based strategy to reduce Salmonella infection in human gut.