Iron supplementation is associated with glucose impairment and hypertension in midpregnancy. - GreenMedInfo Summary
Iron supplementation and gestational diabetes in midpregnancy.
Am J Obstet Gynecol. 2009 Aug ;201(2):158.e1-6. Epub 2009 Jun 13. PMID: 19527900
Department of Internal Medicine, University of Turin, Corso Dogliotti 14, Turin 10126, Italy. firstname.lastname@example.org
OBJECTIVE: Iron supplementation in pregnancy seems beneficial for neonatal/maternal outcomes, but it was associated with diabetes and hypertension in the general population.
STUDY DESIGN: We investigated the association between iron supplementation during midpregnancy and metabolic/hypertensive abnormalities in 500 consecutive gestational diabetes mellitus (GDM) and 500 normoglycemic women.
RESULTS: Iron-supplement users (n = 212/1000) showed significantly higher values of prepregnancy body mass index (BMI), actual BMI, waist circumference, blood pressure, fasting glucose, Homeostasis-Model-Assessment-Insulin-Resistance, and lower high-density lipoprotein-cholesterol than nonusers. The prevalence of GDM (70.8% vs 44.4%), hypertension (25.9% vs 9.8%), metabolic syndrome (25.9% vs 10.4%) was significantly higher in the former with a 2- to 3-fold-increased risk at multiple regression analyses. Most glucose values of the oral glucose tolerance test were significantly higher in iron supplemented women, both in GDM and normoglycemic individuals.
CONCLUSION: Iron supplementation is associated with glucose impairment and hypertension in midpregnancy; its potential harmful effects might be carefully debated regarding its effectiveness.