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Article Publish Status: FREE
Abstract Title:

Inhibitory effect of probiotic Lactobacillus supernatants from the oral cavity on Streptococcus mutans biofilms.

Abstract Source:

Microb Pathog. 2018 Oct ;123:361-367. Epub 2018 Jul 24. PMID: 30053602

Abstract Author(s):

Rodnei Dennis Rossoni, Marisol Dos Santos Velloso, Patrícia Pimentel de Barros, Janaina Araújo de Alvarenga, Jéssica Diane Dos Santos, Ana Carolina Chipoletti Dos Santos Prado, Felipe de Camargo Ribeiro, Ana Lia Anbinder, Juliana Campos Junqueira

Article Affiliation:

Rodnei Dennis Rossoni

Abstract:

Probiotics can release bioactive substances that can inhibit the growth and biofilm formation of pathogenic microorganisms such as Streptococcus mutans. In this context, we evaluated whether the supernatants of Lactobacillus strains isolated from caries-free subjects can inhibit S. mutans, one of the most important bacteria for dental caries. First, the supernatants of 22 Lactobacillus strains were screened for antibacterial activity against S. mutans in planktonic cultures. All 22 Lactobacillus strains studied (100%) showed antibacterial activity. Thereafter, the Lactobacillus strains with the greatest reductions in the planktonic S. mutans cultures were tested on biofilms. The L. fermentum 20.4, L. paracasei 11.6, L. paracasei 20.3 and L. paracasei 25.4 strains could significantly reduce the number of S. mutans cells in biofilms formed in hydroxyapatite (p < 0.05). This reduction was also confirmed by scanning electron microscopy analysis and was not caused by the decreased pH value in the medium (p > 0.05). In addition, the supernatants of these probiotic strains could also reduce the total biomass of S. mutans biofilms (p < 0.05). In conclusion, most of the Lactobacillus strains tested have some antibacterial activity against S. mutans. L. fermentum 20.4, L. paracasei 11.6, L. paracasei 20.3 and L. paracasei 25.4 produce bioactive substances that caused a significant reduction in S. mutans biofilms.

Study Type : Animal Study

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Sayer Ji
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