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Article Publish Status: FREE
Abstract Title:

Improved antitumor activity of cisplatin combined with Ganoderma lucidum polysaccharides in U14 cervical carcinoma-bearing mice.

Abstract Source:

Kaohsiung J Med Sci. 2019 Apr ;35(4):222-229. Epub 2019 Apr 8. PMID: 30958641

Abstract Author(s):

Jun Zhu, Jia Xu, Ling-Ling Jiang, Jin-Qun Huang, Jin-Yu Yan, Yi-Wan Chen, Qian Yang

Article Affiliation:

Jun Zhu

Abstract:

Research on anticervical cancer is urgently required to enhance clinical outcomes. As a main anticancer drug for cervical carcinoma, cisplatin (CIS) has been used for a lot of years in clinical therapy. However, serious adverse effects including nephrotoxicity and neurotoxicity limit its long-term treatment. Our main goal of this study is to investigate the improvement of Ganoderma lucidum polysaccharides (GPS) on CIS-induced antitumor effect of in U14 cervical carcinoma-bearing mice. The results showed that GPS + CIS could not only inhibit the growth of the tumor but also improve the spleen and thymus indexes. Moreover, little toxicological effects were observed on hepatic function and renal function in GPS + CIS treated mice bearing U14 tumor cells. Further analysis of the tumor inhibition mechanism indicated that the number of apoptotic tumor cells increased significantly, the expression of Bax increased and the expression of Bcl-2 decreased dramatically in cervical cancer sections after oral administration of GPS + CIS for 14 days. This GPS/CIS combined therapy represents intriguingtherapeutic strategy for U14 cervical carcinoma providing not only superior efficacy but also a higher safety level.

Study Type : Animal Study

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Sayer Ji
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