Ibuprofen has a genotoxic affect in mouse bone marrow cells. - GreenMedInfo Summary
Genotoxicity of ibuprofen in mouse bone marrow cells in vivo.
Drug Chem Toxicol. 2012 Jan 27. Epub 2012 Jan 27. PMID: 22283434
Sarvajanik Pharmacy College , Gujarat , India.
Genotoxicity of ibuprofen was evaluated by employing the mouse in vivo chromosomal aberration (CA) test. Ibuprofen administered orally at doses of 10, 20, 40, and 60 mg/kg body weight to mice resulted in mitotic depression and induction of CAs. A dose-related decrease in mitotic index (MI) and an increase in the frequencies of chromosomal aberrations per cell (CAs/cell) were recorded in bone marrow cells. However, a statistically significant reduction in MI and an increase in CAs/cell were found for both the higher doses. The results obtained indicate that ibuprofen is capable of inducing dose-dependent genotoxicity in bone marrow cells of mice.