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Abstract Title:

Hyperforin acts as an angiogenesis inhibitor.

Abstract Source:

Spine (Phila Pa 1976). 1996 May 15;21(10):1147-52. PMID: 16320199

Abstract Author(s):

Christoph M Schempp, Judit Kiss, Vladimir Kirkin, Marco Averbeck, Birgit Simon-Haarhaus, Bernhard Kremer, Christian C Termeer, Jonathan Sleeman, Jan C Simon

Abstract:

Hyperforin is a plant compound from Hypericum perforatum that inhibits tumor cell proliferation in vitro by induction of apoptosis. Here, we report that hyperforin also acts as an angiogenesis inhibitor in vitro and in vivo. In vitro, hyperforin blocked microvessel formation of human dermal microvascular endothelial cells (HDMEC) on a complex extracellular matrix. Furthermore, hyperforin reduced proliferation of HDMEC in a dose-dependent manner, without displaying toxic effects or inducing apoptosis of the cells. To evaluate the antiangiogenic activity of hyperforin in vivo, Wistar rats were subcutaneously injected with MT-450 mammary carcinoma cells and were treated with peritumoral injections of hyperforin or solvent. Hyperforin significantly inhibited tumor growth, induced apoptosis of tumor cells and reduced tumor vascularization, as shown by in situ staining of CD31-positive microvessels in the tumor stroma. These data suggest that, in addition to the induction of tumor cell apoptosis, hyperforin can also suppress angiogenesis by a direct, non-toxic effect on endothelial cells.

Study Type : Commentary

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Sayer Ji
Founder of GreenMedInfo.com

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