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Abstract Title:

Sugar-sweetened beverage intake and cancer recurrence and survival in CALGB 89803 (Alliance).

Abstract Source:

PLoS One. 2014 ;9(6):e99816. Epub 2014 Jun 17. PMID: 24937507

Abstract Author(s):

Michael A Fuchs, Kaori Sato, Donna Niedzwiecki, Xing Ye, Leonard B Saltz, Robert J Mayer, Rex B Mowat, Renaud Whittom, Alexander Hantel, Al Benson, Daniel Atienza, Michael Messino, Hedy Kindler, Alan Venook, Shuji Ogino, Kana Wu, Walter C Willett, Edward L Giovannucci, Jeffrey A Meyerhardt

Article Affiliation:

Michael A Fuchs

Abstract:

BACKGROUND: In colon cancer patients, obesity, sedentary lifestyle, and high dietary glycemic load have been associated with increased risk of cancer recurrence. High sugar-sweetened beverage intake has been associated with obesity, diabetes, and cardio-metabolic diseases, but the influence on colon cancer survival is unknown.

METHODS: We assessed the association between sugar-sweetened beverage consumption on cancer recurrence and mortality in 1,011 stage III colon cancer patients who completed food frequency questionnaires as part of a U.S. National Cancer Institute-sponsored adjuvant chemotherapy trial. Hazard ratios (HRs) and 95% confidence intervals (CIs) were calculated with Cox proportional hazard models.

RESULTS: Patients consuming≥ 2 servings of sugar-sweetened beverages per day experienced an adjusted HR for disease recurrence or mortality of 1.67 (95% CI, 1.04-2.68), compared with those consuming<2 servings per month (P(trend) = 0.02). The association of sugar-sweetened beverages on cancer recurrence or mortality appeared greater among patients who were both overweight (body mass index≥ 2 5 kg/m(2)) and less physically active (metabolic equivalent task-hours per week<18) (HR = 2.22; 95% CI, 1.29-3.81, P(trend) = 0.0025).

CONCLUSION: Higher sugar-sweetened beverage intake was associated with a significantly increased risk of cancer recurrence and mortality in stage III colon cancer patients.

Study Type : Animal Study

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Sayer Ji
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