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Abstract Title:

[Harmine induces apoptosis in human SGC-7901 cells].

Abstract Source:

Zhong Yao Cai. 2006 Jun ;29(6):571-3. PMID: 17039880

Abstract Author(s):

Zhen-ya Song, Ji-ren Liu, Xin-liang Lu, Liang-jing Wang

Article Affiliation:

Zhen-ya Song

Abstract:

OBJECTIVE: [corrected] To investigate the effect of apoptosis induced in human SGC-7901 cells by Harmine.

METHODS: The effect of Harmine on human SGC-7901 cell survival and apoptosis was determined by MTT assay, light microscopy and flow cytometry. Cell genomic DNA was detected by agarose electrophoresis.

RESULTS: The survival of human SGC-7901 cells decreased; Apoptotic cells were observed by fluorescent microscope; FCM analysis showed that the peak of apoptosis increased. Typical DNA Ladder were detected in DNA agarose gel electrophoresis.

CONCLUSION: HM can induce apoptosis in human SGC-7901 cells.

Study Type : In Vitro Study
Additional Links
Pharmacological Actions : Apoptotic : CK(5217) : AC(3846)

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Sayer Ji
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