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Abstract Title:

Harmine combined with paclitaxel inhibits tumor proliferation and induces apoptosis through down-regulation of cyclooxygenase-2 expression in gastric cancer.

Abstract Source:

Oncol Lett. 2016 Aug ;12(2):983-988. Epub 2016 Jun 9. PMID: 27446381

Abstract Author(s):

Xiao-Juan Yu, Kun Sun, Xiao-He Tang, Cun-Jin Zhou, Hui Sun, Zhe Yan, Ling Fang, Hong-Wen Wu, Yi-Kui Xie, Bin Gu

Article Affiliation:

Xiao-Juan Yu

Abstract:

Cyclooxygenase-2 (COX-2) serves an important role in the carcinogenesis and progression of gastric cancer. Harmine (HM) and paclitaxel (PTX) are reported as promising drug candidates for cancer therapy, but whether a synergistic anti-tumor effect of HM combined with PTX exists in human gastric cancer remains unknown. The present study evaluated the effects of HM and/or PTX on cell proliferation and apoptosis in a gastric cancer cell line, SGC-7901. HM and PTX inhibited cell proliferation in a dose-dependent manner. Both HM and PTX alone induced apoptosis in gastric cancer cells. The combination of HM and PTX exerted synergistic effects on proliferation inhibition and apoptosis induction in SGC-7901 cells, with down-regulation of COX-2, PCNA and Bcl-2 and up-regulation of Bax expression. The results indicated that combination chemotherapy using HM with PTX exerts an anti-tumor effect for treating gastric cancer. The combination of the two drugs inhibits gastric cancer development more effectively than each drug alone through down-regulation of COX-2 expression.

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Sayer Ji
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