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Abstract Title:

Early-Life Gut Dysbiosis: A Driver of Later-Life Fibrosis?

Abstract Source:

J Invest Dermatol. 2017 Nov ;137(11):2253-2255. PMID: 29055411

Abstract Author(s):

Karen J Ho, John Varga

Article Affiliation:

Karen J Ho

Abstract:

Using a novel mouse model of scleroderma induced by immunization with topoisomerase-I peptide-loaded dendritic cells, Mehta et al. found that early-life antibiotic exposure resulted in increased later-life fibrosis in the skin and lungs. These observations advance the novel concept that gut microbiome alterations caused by early-life exposures may contribute to scleroderma pathogenesis, and warrant in-depth characterization and validation in complementary disease models.

Study Type : Review

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Sayer Ji
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