Glipizide exhibits photoxicity in vitro. - GreenMedInfo Summary
Studies on the in vitro phototoxicity of the antidiabetes drug glipizide.
In Vitr Mol Toxicol. 2000;13(1):17-24. PMID: 10900404
Laboratorio de Fotoquímica, Centro de Quíimica, Instituto Venezolano de Insvestigaciones Científicas, I.V.I.C., Apartado 21827, Caracas Venezuela. email@example.com
The phototoxic antidiabetes drug glipizide (1) is photolabile under aerobic conditions and UV-B light. Irradiation of a phosphate-buffered solution of 1 under oxygen atmosphere produces 4 photoproducts as well as singlet oxygen, which was detected by trapping it with 2,5-dimethylfuran and by the histidine test. The photochemistry of 1 involves cleavage of the sulfonamine and the sulfonamine-R bonds. Red blood cell lysis, photosensitized by glipizide and the products of its aerobic photolysis were demonstrated. The photohemolysis rate was lower for 1 than for its photoproducts. Inhibition of this process on addition of 1, 4-diazabicyclo[2.2.2]octane (DABCO), reduced glutathione (GSH), Vitamin C, sodium azide, superoxide dismutase, and a-tocopherol confirmed the possibility of singlet oxygen, superoxide ion and free radicals participation. Furthermore, in a lipid-photoperoxidation test with linoleic acid the in vitro phototoxicity of glipizide was also verified. A low decreasing cell viability of lymphocytes and neutrophils was observed.