Sayer Ji
Founder of GreenMedInfo.com

Subscribe to our informative Newsletter & get Nature's Evidence-Based Pharmacy

Our newsletter serves 500,000 with essential news, research & healthy tips, daily.

Download Now

500+ pages of Natural Medicine Alternatives and Information.

n/a
Article Publish Status: FREE
Abstract Title:

Ginsenoside Rb1 inhibit apoptosis in rat model of Alzheimer's disease induced by Aβ.

Abstract Source:

Am J Transl Res. 2018 ;10(3):796-805. Epub 2018 Mar 15. PMID: 29636869

Abstract Author(s):

Yiru Wang, Yan Li, Wenyu Yang, Shiyu Gao, Jianwei Lin, Tianqi Wang, Kailiang Zhou, Haiyan Hu

Article Affiliation:

Yiru Wang

Abstract:

Alzheimer's disease (AD) is the most common form of dementia and lacks disease-altering treatments. Ginsenoside Rb1 (GsRb1), the key active compounds of ginsenoside found in ginseng. The present study aimed to determine whether GsRb1 could prevent cognitive deficit and take neuroprotective effects in Aβ-induced rat model through apoptotic signaling pathway. Injection of soluble Aβinto the hippocampus caused impairment in learning and memory. Daily administration of Rb1 (12.5, 25, and 50 mg/kg,) for 14 consecutive days. All rats were tested for their capabilities of spatial navigation and memorization by Morris water maze. Apoptosis was tested using TUNEL staining in hippocampus neuronal cells. RT-PCR, immunohistochemical staining and western blotting were employed to confirm the expressions of Bcl-2, Bax and Cleaved Caspase-3. The results showed that Rb1 administration could prevent cognitive deficit, and significantly decreased the levels of Bax and Cleaved Caspase-3 meanwhile up regulation the level of Bcl-2 in the hippocampus. We suggest that GsRb1 may be effective for preventing or slowing the development of Alzheimer's disease, which improving cognitive and memory functions by inhibiting the levels of pro-apoptosis mediators and improving the levels of anti-apoptosis mediators in the rat brain.

Study Type : Animal Study

Print Options


Key Research Topics

Sayer Ji
Founder of GreenMedInfo.com

Subscribe to our informative Newsletter & get Nature's Evidence-Based Pharmacy

Our newsletter serves 500,000 with essential news, research & healthy tips, daily.

Download Now

500+ pages of Natural Medicine Alternatives and Information.

This website is for information purposes only. By providing the information contained herein we are not diagnosing, treating, curing, mitigating, or preventing any type of disease or medical condition. Before beginning any type of natural, integrative or conventional treatment regimen, it is advisable to seek the advice of a licensed healthcare professional.

© Copyright 2008-2019 GreenMedInfo.com, Journal Articles copyright of original owners, MeSH copyright NLM.