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Abstract Title:

Ginger extracts influence the expression of IL-27 and IL-33 in the central nervous system in experimental autoimmune encephalomyelitis and ameliorates the clinical symptoms of disease.

Abstract Source:

J Neuroimmunol. 2014 Nov 15 ;276(1-2):80-8. Epub 2014 Aug 19. PMID: 25175065

Abstract Author(s):

A Jafarzadeh, M Mohammadi-Kordkhayli, R Ahangar-Parvin, V Azizi, H Khoramdel-Azad, A Shamsizadeh, A Ayoobi, M Nemati, Z M Hassan, S M Moazeni, M Khaksari

Article Affiliation:

A Jafarzadeh

Abstract:

The immunomodulatory effects of the IL-27 and IL-33 and the anti-inflammatory effects of ginger have been reported in some studies. The aim was to evaluate the effects of the ginger extract on the expression of IL-27 and IL-33 in a model of experimental autoimmune encephalomyelitis (EAE). In PBS-treated EAE mice the expression of IL-27 P28 was significantly lower whereas the expression of IL-33 was significantly higher than unimmunized control mice. In 200 and 300 mg/kg ginger-treated EAE groups the expression of IL-27 P28 and IL-27 EBI3 was significantly higher whereas the expression of IL-33 was significantly lower than PBS-treated EAE mice. The EAE clinical symptoms and the pathological scores were significantly lower in ginger-treated EAE groups. These results showed that the ginger extract modulates the expression of the IL-27 and IL-33 in the spinal cord of EAE mice and ameliorates the clinical symptoms of disease.

Study Type : Animal Study

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Sayer Ji
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