Sayer Ji
Founder of GreenMedInfo.com

Subscribe to our informative Newsletter & get Nature's Evidence-Based Pharmacy

Our newsletter serves 500,000 with essential news, research & healthy tips, daily.

Download Now

500+ pages of Natural Medicine Alternatives and Information.

n/a

Abstract Title:

The effect of genistein on glucose control and insulin sensitivity in postmenopausal women: A meta-analysis.

Abstract Source:

Maturitas. 2017 Mar ;97:44-52. Epub 2016 Dec 28. PMID: 28159061

Abstract Author(s):

Yang Liu, Jiapeng Li, Tiansheng Wang, Yitong Wang, Libo Zhao, Yi Fang

Article Affiliation:

Yang Liu

Abstract:

Preclinical studies have revealed the beneficial effects of genistein in pancreaticβ-cell functions. The results of randomized controlled trials (RCTs) in assessing the effects of genistein on glucose metabolism are inconsistent, however. The aim of this meta-analysis is to evaluate the effects of genistein on glucose control and insulin sensitivity in postmenopausal women. Thisstudy searched the Medline, PubMed, and Cochrane databases, and ClinicalTrials.gov for trials from January 1970 to February 2016. We included RCTs that investigated the effects of genistein on glucose control and insulin metabolism in postmenopausal women. We also performed pooled analyses with weighted mean difference (WMD) and 95% confidence intervals (CI) according to the RevMan 5.3 software with the random-effects model. Seven eligible RCTs with 670 participants were included in the meta-analysis. Compared with placebos, genistein exhibited significant effects in lowering fasting glucose levels (WMD, -6.35mg/dL [95% CI, -10.78 to -1.93]; P=0.005), fasting insulin concentrations (WMD, -1.92μIU/mL [95% CI, -3.04 to -0.79]; P=0.0008), and HOMA-IR values (WMD, -0.74 [95% CI, -1.21 to -0.28]; P=0.002). Genistein significantly improves glucose control and insulin sensitivity in postmenopausal women. Long-term treatment may have greater effects than short-term use. The role and safety of genistein in glucose control in postmenopausal women require further investigation.

Print Options


Key Research Topics

Sayer Ji
Founder of GreenMedInfo.com

Subscribe to our informative Newsletter & get Nature's Evidence-Based Pharmacy

Our newsletter serves 500,000 with essential news, research & healthy tips, daily.

Download Now

500+ pages of Natural Medicine Alternatives and Information.

This website is for information purposes only. By providing the information contained herein we are not diagnosing, treating, curing, mitigating, or preventing any type of disease or medical condition. Before beginning any type of natural, integrative or conventional treatment regimen, it is advisable to seek the advice of a licensed healthcare professional.

© Copyright 2008-2019 GreenMedInfo.com, Journal Articles copyright of original owners, MeSH copyright NLM.