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Abstract Title:

Effects of genistein on hot flushes in early postmenopausal women: a randomized, double-blind EPT- and placebo-controlled study.

Abstract Source:

Menopause. 2004 Jul-Aug;11(4):400-4. PMID: 15243277

Abstract Author(s):

Alessandra Crisafulli, Herbert Marini, Alessandra Bitto, Domenica Altavilla, Giovanni Squadrito, Adolfo Romeo, Elena B Adamo, Rolando Marini, Rosario D'Anna, Francesco Corrado, Sebastiano Bartolone, Nicola Frisina, Francesco Squadrito

Article Affiliation:

Department of Clinical and Experimental Medicine and Pharmacology, School of Medicine, University of Messina, Via C.Valeria, 98125 Gazzi, Messina, Italy.

Abstract:

OBJECTIVE: We evaluated and compared the effects of the phytoestrogen genistein, estrogen-progestogen therapy (EPT), and placebo on hot flushes and endometrial thickness in postmenopausal women.

DESIGN: Ninety healthy, postmenopausal women, 47 to 57 years of age, were randomly assigned to receive for 1 year continuous EPT (n = 30; 1 mg 17beta-estradiol combined with 0.5 mg norethisterone acetate), the phytoestrogen genistein (n = 30; 54 mg/day), or placebo (n = 30). Endometrial safety was evaluated by intravaginal ultrasounds at baseline, 6 and 12 months.

RESULTS: By comparison with placebo, daily flushes reduced significantly by a mean of 22% (95% CI: -38 to -6.2; P<0.01) after 3 months, by a mean of 29% (95% CI: -45 to -13; P<0.001) after 6 months, and by a mean of 24% (95% CI: -43 to -5; P<0.01) after 12 months of genistein treatment. Flush score decreased by a mean of 53% (95% CI: -79 to -26; P<0.001) after 3 months, by a mean of 56% (95% CI: -83 to -28; P<0.001) after 6 months, and by a mean of 54% (95% CI: -74 to -33; P<0.001) after 12 months of EPT, as compared with placebo. No side effect was observed on the uterus of the participants.

CONCLUSIONS: The present study confirms that genistein might have positive effects on hot flushes without a negative impact on endometrial thickness and suggests a future role of this phytoestrogen as a strategically therapeutic alternative in the management of postmenopausal symptoms.

Study Type : Human Study

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Sayer Ji
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